Brøns, Charlotte2; Lilleøre, S K3; Jensen, C B3; Toubro, Søren6; Vaag, A2; Astrup, Arne7
1 Obesity Research, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet2 Steno Diabetes Center, Gentofte & Department of Endocrinology (Diabetes and Metabolism), Rigshospitalet, Copenhagen3 Novo Nordisk A/S4 Study and Students´ Affairs, Faculty Services, Faculty of Life Sciences, Københavns Universitet5 Department of Nutrition, Exercise and Sports, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet6 Study and Students´ Affairs, Faculty Services, Faculty of Life Sciences, Københavns Universitet7 Department of Nutrition, Exercise and Sports, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
Results from 24-h whole-body respiratory chamber measurements
OBJECTIVE: Low birth weight (LBW), a marker of disturbed fetal growth, is associated with adiposity and increased risk of type 2 diabetes (T2D). The aim of the study was to investigate whether LBW is associated with changes in 24-h energy expenditure (EE) and/or substrate utilization rates, potentially contributing to the development of adiposity and/or T2D compared to matched control subjects. MATERIALS/METHODS: Forty-six young, healthy men were included in the study; 20 with LBW (= 10th percentile) and 26 control subjects with normal birth weight (NBW) (50th-90th percentile). The subjects were fed a weight maintenance diet and 24-h energy expenditure (EE), respiratory quotient (RQ), and substrate oxidation were assessed in a respiratory chamber. RESULTS: No differences in 24-h EE, RQ or substrate oxidation were observed between LBW and controls. Interestingly, the LBW group exhibited lower nocturnal RQ compared to controls (0.81 ± 0.01 vs. 0.85 ± 0.01 (mean ± SE), P = 0.01), and hence higher nocturnal fat oxidation (2.55 ± 0.13 vs. 2.09 ± 0.12 kJ/min (mean ± SE), P = 0.02). CONCLUSIONS: Young LBW men do not exhibit reductions in 24-h EE. However, LBW subjects display increased nocturnal fat oxidation at the expense of reduced glucose oxidation. We speculate that this may be associated with insufficient capability to retain fat in subcutaneous adipose tissue after meals during day time, with an increased rate of nocturnal and morning lipolysis, and potentially with subtle elevations of gluconeogenesis and of fasting glucose levels in the LBW subjects.
Metabolism, 2013, Vol 62, Issue 5, p. 709-716
Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Adult; Circadian Rhythm; Denmark; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Lipid Metabolism; Lipolysis; Male; Oxidation-Reduction; Respiration; Respiratory Function Tests; Time Factors; Up-Regulation; Young Adult