Kaspersen, Maja Døvling8; Bungum, Mona4; Fedder, Jens5; Bonde, Jesper6; Larsen, Peter B.7; Ingerslev, Hans Jakob9; Höllsberg, Per8
1 Department of Biomedicine - Medical Microbiology and Immunology, Department of Biomedicine, Health, Aarhus University2 Department of Clinical Medicine - Department of Obstetrics and Gynaecology, Department of Clinical Medicine, Health, Aarhus University3 Department of Biomedicine - Forskning og uddannelse, Øst, Department of Biomedicine, Health, Aarhus University4 Reproductive Medicine Centre, Malmö, Sweden5 University of Southern Denmark6 Department of Pathology, Hvidovre Hospital7 Cryos International Sperm Bank8 Department of Biomedicine - Forskning og uddannelse, Øst, Department of Biomedicine, Health, Aarhus University9 Department of Clinical Medicine - Department of Obstetrics and Gynaecology, Department of Clinical Medicine, Health, Aarhus University
It remains unknown whether human papillomaviruses (HPVs) or human herpesviruses (HHVs) in semen affect sperm DNA integrity. We investigated whether the presence of these viruses in semen was associated with an elevated sperm DNA fragmentation index. Semen from 76 sperm donors was examined by a PCR-based hybridization array that identifies all HHVs and 35 of the most common HPVs. Sperm DNA integrity was determined by the sperm chromatin structure assay. HPVs or HHVs, or both, were found in 57% of semen samples; however, sperm DNA fragmentation index was not increased in semen containing these viruses.
Andrology, 2013, Vol 1, Issue 3, p. 1-4
Journal Article; Research Support, Non-U.S. Gov't; DNA Fragmentation; Herpesviridae; Humans; Male; Papillomaviridae; Polymerase Chain Reaction; Semen