IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whether a similar IgE/TNF-α/MMP-9 axis exists in the human basophil. The purpose of this study was thus to investigate whether IgE-mediated activation of human basophils induces TNF-α and MMP-9 release.
Allergy, 2013, Vol 68, Issue 5, p. 614-620
Basophils; IgE-mediated activation; monocytes; tissue remodelling; TNF-alpha; The Faculty of Health and Medical Sciences; Antibodies, Anti-Idiotypic; Cells, Cultured; Histamine Release; Humans; Immunoglobulin E; Leukocytes, Mononuclear; Matrix Metalloproteinase 9; Monocytes; Tumor Necrosis Factor-alpha; Journal Article