Falkencrone, S4; Poulsen, L K3; Bindslev-Jensen, Carsten4; Woetmann, A3; Odum, N3; Poulsen, B C3; Blom, L3; Jensen, B M3; Gibbs, B F3; Yasinska, I M3; Sumbayev, V V3; Skov, P S4
1 Dermato-venerology and Allergy Centre, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU2 ORCA, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU3 unknown4 Dermato-venerology and Allergy Centre, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU
IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whether a similar IgE/TNF-α/MMP-9 axis exists in the human basophil. The purpose of this study was thus to investigate whether IgE-mediated activation of human basophils induces TNF-α and MMP-9 release.
Allergy, 2013, Vol 68, Issue 5, p. 614-20
Antibodies, Anti-Idiotypic; Basophils; Cells, Cultured; Histamine Release; Humans; Immunoglobulin E; Leukocytes, Mononuclear; Matrix Metalloproteinase 9; Monocytes; Tumor Necrosis Factor-alpha; The Faculty of Health and Medical Sciences; IgE-mediated activation; monocytes; tissue remodelling; TNF-alpha; Journal Article