A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provided a new entry for the total synthesis of the antileukemic natural product violacein.
Abstracts of Papers of the American Chemical Society, 2013, Vol 245, Issue 8, p. 1986-1989
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245th National Spring Meeting of the American-Chemical-Society, 2013