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Response to GH treatment in adult GH deficiency is predicted by gender, age, and IGF1 SDS but not by stimulated GH-peak

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Authors:
  • Feldt-Rasmussen, Ulla ;
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    Section of Orthopaedics and Internal Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Brabant, Georg ;
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    unknown
  • Maiter, Dominique ;
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    unknown
  • Jonsson, Björn ;
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    unknown
  • Toogood, Andy ;
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    unknown
  • Koltowska-Haggstrom, Maria ;
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    unknown
  • Rasmussen, Åse Krogh ;
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    Graduate School of Health and Medical Sciences, Graduate School of Health and Medical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
  • Buchfelder, Michael ;
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    unknown
  • Saller, Bernhard ;
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    unknown
  • Biller, Beverly M K
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    unknown
DOI:
10.1530/EJE-13-0005
Abstract:
We studied whether the severity of GH deficiency (GHD) defined as i) GH-peak on stimulation tests (insulin tolerance test (ITT), arginine, and glucagon), ii) number of additional pituitary deficits, or iii) baseline IGF1 SDS could impact the response to GH treatment. We further explored whether iv) IGF1 SDS after 24 months of GH replacement or v) ΔIGF1 SDS from baseline to 24 months was related to the phenotypic response to GH treatment. DESIGN, PATIENTS, AND MEASUREMENTS: The patient cohort (n=1752; 50% women) was obtained from KIMS (Pfizer International Metabolic Database). The patients were divided into three groups of approximately equal size (tertiles) according to the stimulated GH-peak values and baseline IGF1 SDS and were studied at baseline, 12, and 24 months of GH therapy.
Type:
Journal article
Language:
English
Published in:
European Journal of Endocrinology, 2013, Vol 168, Issue 5, p. 733-743
Keywords:
Adult; Age Factors; Aged; Blood Pressure; Body Weight; Cholesterol; Databases, Factual; Female; Hormone Replacement Therapy; Human Growth Hormone; Humans; Hypopituitarism; Insulin-Like Growth Factor I; Male; Middle Aged; Quality of Life; Sex Factors; Treatment Outcome; Triglycerides; Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
240699505

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