Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).
P L O S One, 2013, Vol 8, Issue 4
Journal Article; Research Support, Non-U.S. Gov't; Cell Line, Tumor; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 20; Cohort Studies; Colorectal Neoplasms; DNA Topoisomerases, Type I; Female; Gene Dosage; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Neoplasm Staging; Prognosis