Walsh, Michael2; Merkel, Peter A3; Peh, Chen Au3; Szpirt, Wladimir1; Guillevin, Loïc3; Pusey, Charles D3; De Zoysa, Janak3; Ives, Natalie3; Clark, William F3; Quillen, Karen3; Winters, Jeffrey L3; Wheatley, Keith3; Jayne, David3
1 Department of Nephrology, Abdominal Centre, Rigshospitalet, The Capital Region of Denmark2 Departments of Medicine and Clinical Epidemiology & Biostatistics, Marian Wing, Division of Nephrology, McMaster University, St, Joseph's Hospital, 50 Charlton Ave East, Hamilton, ON L8S 4A6, Canada. firstname.lastname@example.org unknown
protocol for a randomized controlled trial
Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated with high rates of morbidity and mortality due to uncontrolled disease and treatment toxicity. Small randomized trials suggest adjunctive plasma exchange may improve disease control, while observational evidence suggests that current oral glucocorticoid doses are associated with severe infections in patients with AAV. A randomized study of both plasma exchange and glucocorticoids is required to evaluate plasma exchange and oral glucocorticoid dosing in patients with AAV.
Trials, 2013, Vol 14
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Clinical Protocols; Glucocorticoids; Humans; Plasma Exchange; Sample Size