a trial protocol for the randomized, clinical, parallel group, assessor and data analyst blinded Pulmonary Protection Trial
Five to thirty percent of patients undergoing cardiac surgery present with chronic obstructive pulmonary disease (COPD) and have a 2- to 10-fold higher 30-day mortality risk. Cardiopulmonary bypass (CPB) creates a whole body systemic inflammatory response syndrome (SIRS) that could impair pulmonary function. Impaired pulmonary function can, however, be attenuated by pulmonary perfusion with oxygenated blood or custodiol HTK (histidine-tryptophan-ketoglutarate) solution.
Trials, 2013, Vol 14
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't