Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- Authors:
-
- Berndt, Sonja I ;
- Gustafsson, Stefan ;
- Mägi, Reedik ;
- Ganna, Andrea ;
- Wheeler, Eleanor ;
- Feitosa, Mary F ;
- Justice, Anne E ;
- Monda, Keri L ;
- Croteau-Chonka, Damien C ;
- Day, Felix R ;
- Esko, Tõnu ;
- Fall, Tove ;
- Ferreira, Teresa ;
- Gentilini, Davide ;
- Jackson, Anne U ;
- Luan, Jian'an ;
- Randall, Joshua C ;
- Vedantam, Sailaja ;
- Willer, Cristen J ;
- Winkler, Thomas W ;
- Wood, Andrew R ;
- Workalemahu, Tsegaselassie ;
- Hu, Yi-Juan ;
- Lee, Sang Hong ;
- Liang, Liming ;
- Lin, Dan-Yu ;
- Min, Josine L ;
- Neale, Benjamin M ;
- Thorleifsson, Gudmar ;
- Yang, Jian ;
- Albrecht, Eva ;
- Amin, Najaf ;
- Bragg-Gresham, Jennifer L ;
- Cadby, Gemma ;
- den Heijer, Martin ;
- Eklund, Niina ;
- Fischer, Krista ;
- Goel, Anuj ;
- Hottenga, Jouke-Jan ;
- Huffman, Jennifer E ;
- Jarick, Ivonne ;
- Johansson, Åsa ;
- Johnson, Toby ;
- Kanoni, Stavroula ;
- Kleber, Marcus E ;
- König, Inke R ;
- Kristiansson, Kati ;
- Kutalik, Zoltán ;
- Lamina, Claudia ;
- Lecoeur, Cecile ;
- Li, Guo ;
- Mangino, Massimo ;
- McArdle, Wendy L ;
- Medina-Gomez, Carolina ;
- Müller-Nurasyid, Martina ;
- Ngwa, Julius S ;
- Nolte, Ilja M ;
- Paternoster, Lavinia ;
- Pechlivanis, Sonali ;
- Perola, Markus ;
- Peters, Marjolein J ;
- Preuss, Michael ;
- Rose, Lynda M ;
- Shi, Jianxin ;
- Shungin, Dmitry ;
- Smith, Albert Vernon ;
- Strawbridge, Rona J ;
- Surakka, Ida ;
- Teumer, Alexander ;
- Trip, Mieke D ;
- Tyrer, Jonathan ;
- Van Vliet-Ostaptchouk, Jana V ;
- Vandenput, Liesbeth ;
- Waite, Lindsay L ;
- Zhao, Jing Hua ;
- Absher, Devin ;
- Asselbergs, Folkert W ;
- Atalay, Mustafa ;
- Attwood, Antony P ;
- Balmforth, Anthony J ;
- Basart, Hanneke ;
- Beilby, John ;
- Bonnycastle, Lori L ;
- Brambilla, Paolo ;
- Bruinenberg, Marcel ;
- Campbell, Harry ;
- Chasman, Daniel I ;
- Chines, Peter S ;
- Collins, Francis S ;
- Connell, John M ;
- Cookson, William O ;
- de Faire, Ulf ;
- de Vegt, Femmie ;
- Dei, Mariano ;
- Dimitriou, Maria ;
- Edkins, Sarah ;
- Estrada, Karol ;
- Evans, David M ;
- Farrall, Martin ;
- Ferrario, Marco M ;
- Ferrières, Jean ;
- Franke, Lude ;
- Frau, Francesca ;
- Gejman, Pablo V ;
- Grallert, Harald ;
- Grönberg, Henrik ;
- Gudnason, Vilmundur ;
- Hall, Alistair S ;
- Hall, Per ;
- Hartikainen, Anna-Liisa ;
- Hayward, Caroline ;
- Heard-Costa, Nancy L ;
- Heath, Andrew C ;
- Hebebrand, Johannes ;
- Homuth, Georg ;
- Hu, Frank B ;
- Hunt, Sarah E ;
- Hyppönen, Elina ;
- Iribarren, Carlos ;
- Jacobs, Kevin B ;
- Jansson, John-Olov ;
- Jula, Antti ;
- Kähönen, Mika ;
- Kathiresan, Sekar ;
- Kee, Frank ;
- Khaw, Kay-Tee ;
- Kivimäki, Mika ;
- Koenig, Wolfgang ;
- Kraja, Aldi T ;
- Kumari, Meena ;
- Kuulasmaa, Kari ;
- Kuusisto, Johanna ;
- Laitinen, Jaana H ;
- Lakka, Timo A ;
- Langenberg, Claudia ;
- Launer, Lenore J ;
- Lind, Lars ;
- Lindström, Jaana ;
- Liu, Jianjun ;
- Liuzzi, Antonio ;
- Lokki, Marja-Liisa ;
- Lorentzon, Mattias ;
- Madden, Pamela A ;
- Magnusson, Patrik K ;
- Manunta, Paolo ;
- Marek, Diana ;
- März, Winfried ;
- Mateo Leach, Irene ;
- McKnight, Barbara ;
- Medland, Sarah E ;
- Mihailov, Evelin ;
- Milani, Lili ;
- Montgomery, Grant W ;
- Mooser, Vincent ;
- Mühleisen, Thomas W ;
- Munroe, Patricia B ;
- Musk, Arthur W ;
- Narisu, Narisu ;
- Navis, Gerjan ;
- Nicholson, George ;
- Nohr, Ellen A ;
- Ong, Ken K ;
- Oostra, Ben A ;
- Palmer, Colin N A ;
- Palotie, Aarno ;
- Peden, John F ;
- Pedersen, Nancy ;
- Peters, Annette ;
- Polasek, Ozren ;
- Pouta, Anneli ;
- Pramstaller, Peter P ;
- Prokopenko, Inga ;
- Pütter, Carolin ;
- Radhakrishnan, Aparna ;
- Raitakari, Olli ;
- Rendon, Augusto ;
- Rivadeneira, Fernando ;
- Rudan, Igor ;
- Saaristo, Timo E ;
- Sambrook, Jennifer G ;
- Sanders, Alan R ;
- Sanna, Serena ;
- Saramies, Jouko ;
- Schipf, Sabine ;
- Schreiber, Stefan ;
- Schunkert, Heribert ;
- Shin, So-Youn ;
- Signorini, Stefano ;
- Sinisalo, Juha ;
- Skrobek, Boris ;
- Soranzo, Nicole ;
- Stančáková, Alena ;
- Stark, Klaus ;
- Stephens, Jonathan C ;
- Stirrups, Kathleen ;
- Stolk, Ronald P ;
- Stumvoll, Michael ;
- Swift, Amy J ;
- Theodoraki, Eirini V ;
- Thorand, Barbara ;
- Tregouet, David-Alexandre ;
- Tremoli, Elena ;
- Van der Klauw, Melanie M ;
- van Meurs, Joyce B J ;
- Vermeulen, Sita H ;
- Viikari, Jorma ;
- Virtamo, Jarmo ;
- Vitart, Veronique ;
- Waeber, Gérard ;
- Wang, Zhaoming ;
- Widén, Elisabeth ;
- Wild, Sarah H ;
- Willemsen, Gonneke ;
- Winkelmann, Bernhard R ;
- Witteman, Jacqueline C M ;
- Wolffenbuttel, Bruce H R ;
- Wong, Andrew ;
- Wright, Alan F ;
- Zillikens, M Carola ;
- Amouyel, Philippe ;
- Boehm, Bernhard O ;
- Boerwinkle, Eric ;
- Boomsma, Dorret I ;
- Caulfield, Mark J ;
- Chanock, Stephen J ;
- Cupples, L Adrienne ;
- Cusi, Daniele ;
- Dedoussis, George V ;
- Erdmann, Jeanette ;
- Eriksson, Johan G ;
- Franks, Paul W ;
- Froguel, Philippe ;
- Gieger, Christian ;
- Gyllensten, Ulf ;
- Hamsten, Anders ;
- Harris, Tamara B ;
- Hengstenberg, Christian ;
- Hicks, Andrew A ;
- Hingorani, Aroon ;
- Hinney, Anke ;
- Hofman, Albert ;
- Hovingh, Kees G ;
- Hveem, Kristian ;
- Illig, Thomas ;
- Jarvelin, Marjo-Riitta ;
- Jöckel, Karl-Heinz ;
- Keinanen-Kiukaanniemi, Sirkka M ;
- Kiemeney, Lambertus A ;
- Kuh, Diana ;
- Laakso, Markku ;
- Lehtimäki, Terho ;
- Levinson, Douglas F ;
- Martin, Nicholas G ;
- Metspalu, Andres ;
- Morris, Andrew D ;
- Nieminen, Markku S ;
- Njølstad, Inger ;
- Ohlsson, Claes ;
- Oldehinkel, Albertine J ;
- Ouwehand, Willem H ;
- Palmer, Lyle J ;
- Penninx, Brenda ;
- Power, Chris ;
- Province, Michael A ;
- Psaty, Bruce M ;
- Qi, Lu ;
- Rauramaa, Rainer ;
- Ridker, Paul M ;
- Ripatti, Samuli ;
- Salomaa, Veikko ;
- Samani, Nilesh J ;
- Snieder, Harold ;
- Sørensen, Thorkild I A ;
- Spector, Timothy D ;
- Stefansson, Kari ;
- Tönjes, Anke ;
- Tuomilehto, Jaakko ;
- Uitterlinden, André G ;
- Uusitupa, Matti ;
- van der Harst, Pim ;
- Vollenweider, Peter ;
- Wallaschofski, Henri ;
- Wareham, Nicholas J ;
- Watkins, Hugh ;
- Wichmann, H-Erich ;
- Wilson, James F ;
- Abecasis, Goncalo R ;
- Assimes, Themistocles L ;
- Barroso, Inês ;
- Boehnke, Michael ;
- Borecki, Ingrid B ;
- Deloukas, Panos ;
- Fox, Caroline S ;
- Frayling, Timothy ;
- Groop, Leif C ;
- Haritunian, Talin ;
- Heid, Iris M ;
- Hunter, David ;
- Kaplan, Robert C ;
- Karpe, Fredrik ;
- Moffatt, Miriam F ;
- Mohlke, Karen L ;
- O'Connell, Jeffrey R ;
- Pawitan, Yudi ;
- Schadt, Eric E ;
- Schlessinger, David ;
- Steinthorsdottir, Valgerdur ;
- Strachan, David P ;
- Thorsteinsdottir, Unnur ;
- van Duijn, Cornelia M ;
- Visscher, Peter M ;
- Di Blasio, Anna Maria ;
- Hirschhorn, Joel N ;
- Lindgren, Cecilia M ;
- Morris, Andrew P ;
- Meyre, David ;
- Scherag, André ;
- McCarthy, Mark I ;
- Speliotes, Elizabeth K ;
- North, Kari E ;
- Loos, Ruth J F ;
- Ingelsson, Erik
- DOI:
- 10.1038/ng.2606
- Abstract:
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
- Type:
- Journal article
- Language:
- English
- Published in:
- Nature Genetics, 2013, Vol 45, Issue 5, p. 501-12
- Keywords:
- Anthropometry; Body Height; Body Mass Index; Case-Control Studies; European Continental Ancestry Group; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Meta-Analysis as Topic; Obesity; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Waist-Hip Ratio; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2014
- Scientific Level:
- Scientific
- ID:
- 240489829
