Olsen, Catherine M2; Nagle, Christina M2; Whiteman, David C2; Ness, Roberta2; Pearce, Celeste Leigh2; Pike, Malcolm C2; Rossing, Mary Anne2; Terry, Kathryn L2; Wu, Anna H2; Risch, Harvey A2; Yu, Herbert2; Doherty, Jennifer A2; Chang-Claude, Jenny2; Hein, Rebecca2; Nickels, Stefan2; Wang-Gohrke, Shan2; Goodman, Marc T2; Carney, Michael E2; Matsuno, Rayna K2; Lurie, Galina2; Moysich, Kirsten2; Kjaer, Susanne K5; Jensen, Allan6; Hogdall, Estrid5; Goode, Ellen L2; Fridley, Brooke L2; Vierkant, Robert A2; Larson, Melissa C2; Schildkraut, Joellen2; Hoyo, Cathrine2; Moorman, Patricia2; Weber, Rachel P2; Cramer, Daniel W2; Vitonis, Allison F2; Bandera, Elisa V2; Olson, Sara H2; Rodriguez-Rodriguez, Lorna2; King, Melony2; Brinton, Louise A2; Yang, Hannah2; Garcia-Closas, Montserrat2; Lissowska, Jolanta2; Anton-Culver, Hoda2; Ziogas, Argyrios2; Gayther, Simon A2; Ramus, Susan J2; Menon, Usha2; Gentry-Maharaj, Aleksandra2; Webb, Penelope M2; Cancer), Australian Cancer Study (Ovarian2
1 Section of Gynaecology, Obstetrics and Paediatrics, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet2 unknown3 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet4 Department of Public Health, Faculty of Health and Medical Sciences, Københavns Universitet5 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet6 Department of Public Health, Faculty of Health and Medical Sciences, Københavns Universitet
evidence from the Ovarian Cancer Association Consortium
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence of obesity has increased dramatically, and classification of ovarian histology has improved in the last decade, we sought to examine the association in a pooled analysis of recent studies participating in the Ovarian Cancer Association Consortium. We evaluated the association between BMI (recent, maximum and in young adulthood) and ovarian cancer risk using original data from 15 case–control studies (13 548 cases and 17 913 controls). We combined study-specific adjusted odds ratios (ORs) using a random-effects model. We further examined the associations by histological subtype, menopausal status and post-menopausal hormone use. High BMI (all time-points) was associated with increased risk. This was most pronounced for borderline serous (recent BMI: pooled OR=1.24 per 5 kg/m2; 95% CI 1.18–1.30), invasive endometrioid (1.17; 1.11–1.23) and invasive mucinous (1.19; 1.06–1.32) tumours. There was no association with serous invasive cancer overall (0.98; 0.94–1.02), but increased risks for low-grade serous invasive tumours (1.13, 1.03–1.25) and in pre-menopausal women (1.11; 1.04–1.18). Among post-menopausal women, the associations did not differ between hormone replacement therapy users and non-users. Whilst obesity appears to increase risk of the less common histological subtypes of ovarian cancer, it does not increase risk of high-grade invasive serous cancers, and reducing BMI is therefore unlikely to prevent the majority of ovarian cancer deaths. Other modifiable factors must be identified to control this disease.
Endocrine - Related Cancer, 2013, Vol 20, Issue 2, p. 251-62
The Faculty of Health and Medical Sciences; ovarian cancer; obesity; BMI; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Body Mass Index; Female; Humans; Neoplasm Grading; Obesity; Odds Ratio; Ovarian Neoplasms; Risk; Societies, Medical