We report a case of a premature girl born with a gestational age of 26 weeks who developed cardiac tamponade after displacement of a peripheral inserted central catheter. She recovered completely after an acutely performed pericardiocentesis. The pericardial fluid was consistent with parental nutrition. Pericardiac effusion must be suspected in children with central catheters and sudden cardiovascular decompensation. This article discusses recommended positioning of peripherally inserted central catheters.