ABSTRACT: BACKGROUND: We evaluated the effectiveness and safety of a zotarolimus-eluting (ZES) versus a sirolimus-eluting (SES) coronary stent in a large cohort of patients treated with one of these stents in Western Denmark. METHODS: A total of 6,122 patients treated with ZES (n = 2,282) or SES (n = 3,840) were followed for up to 27 months. We ascertained clinical outcomes based on national medical databases. RESULTS: Incidence of target lesion revascularization (no. per 100 person-years) was 5.3 in the ZES group compared to 1.9 in the SES group (adjusted hazard ratio (HR) = 2.19, 95% confidence intervals (CI): 1.39-3.47; p = 0.001). All-cause mortality was also higher in the ZES group (ZES: 6.3; SES: 3.3; adjusted HR = 1.34, 95% CI: 1.05-1.72; p = 0.02), while stent thrombosis (ZES: 1.2; SES: 0.5; adjusted HR = 1.98, 95% CI: 0.75-5.23; p = 0.14) did not differ significantly. CONCLUSIONS: In agreement with previously published randomised data, this observational study indicated that the ZES was associated with an increased risk of death and TLR in a large cohort of consecutive patients.
B M C Cardiovascular Disorders, 2012, Vol 12, Issue 1