Wilson, Shona5; Jones, Frances M.5; Fofana, Hassan K. M.3; Doucouré, Aissata3; Landouré, Aly3; Kimani, Gachuhi4; Mwatha, Joseph K.4; Sacko, Moussa3; Vennervald, Birgitte J6; Dunne, David W5
1 Parasitology and Aquatic Diseases, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Københavns Universitet2 University of Cambridge3 Institut National de Recherche en Santé Publique4 Kenya Medical Research Institute5 University of Cambridge6 Parasitology and Aquatic Diseases, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Københavns Universitet
IgE specific to worm antigen (SWA) and pre-treatment eosinophil number, are associated with human immunity to re-infection with schistosomes after chemotherapeutic treatment. Treatment significantly elevates circulating IL-5 24-hr post-treatment of Schistosoma mansoni. Here we investigate if praziquantel treatment of human schistosomiasis haematobium also boosts circulating IL-5, the immunological and parasitological factors that predispose to this, and the relationship between these and subsequent immunity to post-treatment re-infection.
P L O S Neglected Tropical Diseases (online), 2013, Vol 7, Issue 3