Eeles, Rosalind A2; Olama, Ali Amin Al2; Benlloch, Sara2; Saunders, Edward J2; Leongamornlert, Daniel A2; Tymrakiewicz, Malgorzata2; Ghoussaini, Maya2; Luccarini, Craig2; Dennis, Joe2; Jugurnauth-Little, Sarah2; Dadaev, Tokhir2; Neal, David E2; Hamdy, Freddie C2; Donovan, Jenny L2; Muir, Ken2; Giles, Graham G2; Severi, Gianluca2; Wiklund, Fredrik2; Gronberg, Henrik2; Haiman, Christopher A2; Schumacher, Fredrick2; Henderson, Brian E2; Le Marchand, Loic2; Lindstrom, Sara2; Kraft, Peter2; Hunter, David J2; Gapstur, Susan2; Chanock, Stephen J2; Berndt, Sonja I2; Albanes, Demetrius2; Andriole, Gerald2; Schleutker, Johanna2; Weischer, Maren2; Canzian, Federico2; Riboli, Elio2; Key, Tim J2; Travis, Ruth C2; Campa, Daniele2; Ingles, Sue A2; John, Esther M2; Hayes, Richard B2; Pharoah, Paul D P2; Pashayan, Nora2; Khaw, Kay-Tee2; Stanford, Janet L2; Ostrander, Elaine A2; Signorello, Lisa B2; Thibodeau, Stephen N2; Schaid, Dan2; Maier, Christiane2; Vogel, Walther2; Kibel, Adam S2; Cybulski, Cezary2; Lubinski, Jan2; Cannon-Albright, Lisa2; Brenner, Hermann2; Park, Jong Y2; Kaneva, Radka2; Batra, Jyotsna2; Spurdle, Amanda B2; Clements, Judith A2; Teixeira, Manuel R2; Dicks, Ed2; Lee, Andrew2; Dunning, Alison M2; Baynes, Caroline2; Conroy, Don2; Maranian, Melanie J2; Ahmed, Shahana2; Govindasami, Koveela2; Guy, Michelle2; Wilkinson, Rosemary A2; Sawyer, Emma J2; Morgan, Angela2; Dearnaley, David P2; Horwich, Alan2; Huddart, Robert A2; Khoo, Vincent S2; Parker, Christopher C2; Van As, Nicholas J2; Woodhouse, Christopher J2; Thompson, Alan2; Dudderidge, Tim2; Ogden, Chris2; Cooper, Colin S2; Lophatananon, Artitaya2; Cox, Angela2; Southey, Melissa C2; Hopper, John L2; English, Dallas R2; Aly, Markus2; Adolfsson, Jan2; Xu, Jiangfeng2; Zheng, Siqun L2; Yeager, Meredith2; Kaaks, Rudolf2; Diver, W Ryan2; Gaudet, Mia M2; Stern, Mariana C2; Corral, Roman2; Joshi, Amit D2; Shahabi, Ahva2; Wahlfors, Tiina2; Tammela, Teuvo L J2; Auvinen, Anssi2; Virtamo, Jarmo2; Klarskov, Ole Peter2; Nordestgaard, Børge G4; Røder, M Andreas2; Nielsen, Sune F2; Bojesen, Stig E2; Siddiq, Afshan2; Fitzgerald, Liesel M2; Kolb, Suzanne2; Kwon, Erika M2; Karyadi, Danielle M2; Blot, William J2; Zheng, Wei2; Cai, Qiuyin2; McDonnell, Shannon K2; Rinckleb, Antje E2; Drake, Bettina2; Colditz, Graham2; Wokolorczyk, Dominika2; Stephenson, Robert A2; Teerlink, Craig2; Muller, Heiko2; Rothenbacher, Dietrich2; Sellers, Thomas A2; Lin, Hui-Yi2; Slavov, Chavdar2; Mitev, Vanio2; Lose, Felicity2; Srinivasan, Srilakshmi2; Maia, Sofia2; Paulo, Paula2; Lange, Ethan2; Cooney, Kathleen A2; Antoniou, Antonis C2; Vincent, Daniel2; Bacot, François2; Tessier, Daniel C2; Kote-Jarai, Zsofia2; Easton, Douglas F2
1 Section of Diagnostic Sciences, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet2 unknown3 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet4 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P <5 × 10(-8)). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
Nature Genetics, 2013, Vol 45, Issue 4, p. 385-391