Callesen, Nicoline F2; Mathiesen, Jonathan Michael3; Ringholm, Lene2; Damm, Peter5; Mathiesen, Elisabeth R5
1 Section of Orthopaedics and Internal Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet2 unknown3 Afd. for Undervisning4 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet5 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
comparison of glycaemic control and pregnancy outcome
Objective: To compare glycaemic control and pregnancy outcome in women with type 1 diabetes treated with the long-acting insulin analogues detemir or glargine. Methods: Retrospective study of singleton pregnancies from 2007 to 2011 in women with type 1 diabetes with a single living fetus at 22 weeks using either insulin detemir (n = 67) or glargine (n = 46) from conception. Results: Baseline characteristics were similar in the detemir and glargine groups. Haemoglobin A(1c) was comparable at 8 weeks (median 6.6% (range 5.6-9.8) vs. 6.8% (5.4-10.1), p = 0.15) and at 33 weeks (6.1% (5.1-7.6) vs. 6.2% (4.8-7.2), p = 0.38). The incidence of severe hypoglycaemia was comparable (15 (23%) vs. 10 (23%), p = 0.98). Pre-eclampsia occurred in 9 (14%) vs. 8 (18%), p = 0.52, pre-term delivery in 21 (31%) vs. 16 (35%), (p = 0.70) and 33 (49%) vs. 14 (30%) infants were large for gestational age (p = 0.046). No perinatal deaths were observed. One offspring in each group was born with a major congenital malformation. Conclusions: Glycaemic control and pregnancy outcome were comparable in women using insulin detemir or glargine, except for a lower prevalence of large for gestational age infants in women on glargine. The use of both long-acting insulin analogues during pregnancy seems safe.
Journal of Maternal - Fetal and Neonatal Medicine, 2013, Vol 26, Issue 6, p. 588-92
Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Humans; Hypoglycemic Agents; Insulin, Long-Acting; Pregnancy; Pregnancy Outcome; Pregnancy in Diabetics; Retrospective Studies; Young Adult