{"controller"=>"catalog", "action"=>"show", "id"=>"239882742"}
  • EN
  • DA

Danish NationalResearch Database

  • Search Publications & Researchers
  • Open Access Indicator
  • Publications
  • Researchers
Example Finds records
water{} containing the word "water".
water supplies"{}" containing the phrase "water supplies".
author:"Doe, John"author:"{}" containing the prase "Doe, John" in the author field.
title:IEEEtitle:{} containing the word "IEEE" in the title field.
Need more help? Advanced search tutorial
  • Selected (0)
  • History

The chemical interactome space between the human host and the genetically defined gut metabotypes

    • Save to Mendeley
    • Export to BibTeX
    • Export to RIS
    • Email citation
Authors:
  • Jacobsen, Ulrik Plesner ;
    Close
    Department of Bio and Health Informatics, Technical University of Denmark
  • Nielsen, Henrik Bjørn ;
    Close
    Orcid logo0000-0003-2281-5713
    Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
  • Hildebrand, Falk ;
    Close
    Research Group of Bioinformatics and (eco-)systems biology
  • Raes, Jeroen ;
    Close
    Research Group of Bioinformatics and (eco-)systems biology
  • Sicheritz-Pontén, Thomas ;
    Close
    Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
  • Kouskoumvekaki, Irene ;
    Close
    Department of Systems Biology, Technical University of Denmark
  • Panagiotou, Gianni
    Close
    Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
DOI:
10.1038/ismej.2012.141
Abstract:
The bacteria that colonize the gastrointestinal tracts of mammals represent a highly selected microbiome that has a profound influence on human physiology by shaping the host’s metabolic and immune system activity. Despite the recent advances on the biological principles that underlie microbial symbiosis in the gut of mammals, mechanistic understanding of the contributions of the gut microbiome and how variations in the metabotypes are linked to the host health are obscure. Here, we mapped the entire metabolic potential of the gut microiome based solely on metagenomics sequencing data derived from fecal samples of 124 Europeans (healthy, obese and with inflammatory bowel disease). Interestingly, three distinct clusters of individuals with high, medium and low metabolic potential were observed. By illustrating these results in the context of bacterial population, we concluded that the abundance of the Prevotella genera is a key factor indicating a low metabolic potential. These metagenome-based metabolic signatures were used to study the interaction networks between bacteria-specific metabolites and human proteins. We found that thirty-three such metabolites interact with disease-relevant protein complexes several of which are highly expressed in cells and tissues involved in the signaling and shaping of the adaptive immune system and associated with squamous cell carcinoma and bladder cancer. From this set of metabolites, eighteen are present in DrugBank providing evidence that we carry a natural pharmacy in our guts. Furthermore, we established connections between the systemic effects of non-antibiotic drugs and the gut microbiome of relevance to drug side effects and health-care solutions.
Type:
Journal article
Language:
English
Published in:
I S M E Journal, 2013, Vol 7, p. 730-742
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2012
Scientific Level:
Scientific
ID:
239882742

Full text access

  • Openaccess Technical University of Denmark
  • Doi Get publisher edition via DOI resolver
Checking for on-site access...

On-site access

At institution

  • Technical university of dk

Metrics

Feedback

Sitemap

  • Search
    • Statistics
    • Tutorial
    • Data
    • FAQ
    • Contact
  • Open Access
    • Overview
    • Development
    • FAQ
    • Contact
  • About
    • Institutions
    • Release History
    • Cookies and privacy policy

Copyright © 1998–2018.

Fivu en