Effectiveness of high concentration versus prolonged exposure
In healthy subjects, subcutaneous injections of GLP-2 have been shown to elicit dose-related decrease in the bone resorption marker, carboxy-terminal telopeptide of type I collagen (CTX), and have been proposed for the treatment of osteoporosis. This study investigated the relation between GLP-2 exposure and decreases in CTX in order to determine whether high concentrations or prolonged exposure was the most effective mode of administration. High GLP-2 concentrations resulted from iv bolus injections, whereas a more protracted stimulation was obtained by subcutaneous injections and the addition of an inhibitor of GLP-2 degradation, a DPP-4 inhibitor, sitagliptin.
Regulatory Peptides, 2013, Vol 181, p. 4-8
Journal Article; Adult; Area Under Curve; Biological Markers; Bone Resorption; Collagen Type I; Dipeptidyl-Peptidase IV Inhibitors; Drug Administration Schedule; Female; Glucagon-Like Peptide 2; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Middle Aged; Peptide Fragments; Pyrazines; Triazoles