Physical mapping and cloning of RAD56

David P Mathiasen; Irene Gallina; Susanne Manuela Germann; Wissam Hamou; Morgane Eléouët; Sara Thodberg; Nadine Eckert-Boulet; John Game; Michael Lisby

doi:10.1016/j.gene.2013.01.044

Physical mapping and cloning of RAD56

Authors:

Mathiasen, David P ;
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Functional Genomics, Department of Biology, Faculty of Science, Københavns Universitet
Gallina, Irene ;
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Functional Genomics, Department of Biology, Faculty of Science, Københavns Universitet
Germann, Susanne Manuela ;
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Molecular Aging Program, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
Hamou, Wissam ;
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unknown
Eléouët, Morgane ;
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unknown
Thodberg, Sara ;
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unknown
Eckert-Boulet, Nadine ;
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Functional Genomics, Department of Biology, Faculty of Science, Københavns Universitet
Game, John ;
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unknown
Lisby, Michael
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0000-0002-4830-5247
Functional Genomics, Department of Biology, Faculty of Science, Københavns Universitet

DOI:

10.1016/j.gene.2013.01.044

Abstract:

Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.

Type:

Journal article

Language:

English

Published in:

Gene, 2013, Vol 519, Issue 1, p. 182-186

Main Research Area:

Medical science

Publication Status:

Published

Review type:

Peer Review

Submission year:

2013

Scientific Level:

Scientific

ID:

239846079

Physical mapping and cloning of RAD56

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