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Physical mapping and cloning of RAD56

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Authors:
  • Mathiasen, David P ;
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    Functional Genomics, Department of Biology, Faculty of Science, Københavns Universitet
  • Gallina, Irene ;
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    Functional Genomics, Department of Biology, Faculty of Science, Københavns Universitet
  • Germann, Susanne Manuela ;
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    Molecular Aging Program, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Hamou, Wissam ;
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    unknown
  • Eléouët, Morgane ;
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    unknown
  • Thodberg, Sara ;
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    unknown
  • Eckert-Boulet, Nadine ;
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    Functional Genomics, Department of Biology, Faculty of Science, Københavns Universitet
  • Game, John ;
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    unknown
  • Lisby, Michael
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    Orcid logo0000-0002-4830-5247
    Functional Genomics, Department of Biology, Faculty of Science, Københavns Universitet
DOI:
10.1016/j.gene.2013.01.044
Abstract:
Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.
Type:
Journal article
Language:
English
Published in:
Gene, 2013, Vol 519, Issue 1, p. 182-186
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
239846079

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