Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers

Grigoriy Andreev Emiliyanov; Poul E. Høiby; Lars H. Pedersen; Ole Bang

doi:10.3390/s130303242

Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers

Authors:

Emiliyanov, Grigoriy Andreev ;
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Department of Photonics Engineering, Technical University of Denmark
Høiby, Poul E. ;
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DAKO Denmark A/S
Pedersen, Lars H. ;
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Bioneer A/S
Bang, Ole
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Department of Photonics Engineering, Technical University of Denmark

DOI:

10.3390/s130303242

Abstract:

We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated.

Type:

Journal article

Language:

English

Published in:

Sensors, 2013, Vol 13, Issue 3, p. 3242-3251

Keywords:

Microstructured polymer optical fiber; Fluorescence; Antibodies

Main Research Area:

Science/technology

Publication Status:

Published

Review type:

Peer Review

Submission year:

2013

Scientific Level:

Scientific

ID:

239595552

Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers

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