Operationalization and application of “early warning signs” to screen nanomaterials for harmful properties operationalizationand application of “early warning signs” to screen nanomaterials for harmful properties
Hansen, Steffen Foss1; Nielsen, K. N.3; Knudsen, N.4; Grieger, K. D.5; Baun, Anders1
1 Department of Environmental Engineering, Technical University of Denmark2 Environmental Chemistry, Department of Environmental Engineering, Technical University of Denmark3 GenØk4 LEO Pharma A/S5 RTI International
In 2001 the European Environment Agency (EEA) publi shed a report that analyzed 14 cases of technological developments that later on turned out to have negative side-effects and they identified 12 “late lessons” for current and future policy-makers to have in mind when initiating new technological endeavors. This paper explores ho w the first lesson - “Acknowledge and respond to ignorance, uncertainty and risk in techn ology appraisal” could be applied to screen nanomaterials. In cases of ignorance, uncertainty a nd risk, the EEA recommends paying particular attention to important warning signs suc h as novelty, persistency, whether materials are readily dispersed in the environment, whether t hey bioaccumulate or lead to potentially irreversible action. Through an analysis of these c riteria using five well-known nanomaterials (titanium dioxide, carbon nanotubes, liposomes, pol y(lactic-co-glycolic acid) and nanoscale zero-valent iron, and carbon nanotubes), it was fou nd that only nanoTiO2 fulfills all the five criteria. Dependent on the length of the nanotubes, carbon nanotubes fulfills 3 or 4 criteria whereas liposomes, poly(lactic-co-glycolic acid), n anoscale zero-valent iron fulfills only one criteria. Finally, we discuss how these warning sig ns can be used by different stakeholders such as nanomaterial researchers and developers, compani es and regulators to design benign nanomaterials, communicate what is known about nano -risks and decide on whether to implement precautionary regulatory measures.