1 Department of Micro- and Nanotechnology, Technical University of Denmark2 Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark3 Academia Sinica4 Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Center, Technical University of Denmark5 National Taiwan University6 Academia Sinica7 National Taiwan University
Here we report a high-throughput spinning device for nanometric scale measurements of microstructures with instrumentation details and experimental results. The readout technology implemented in the designed disc-like device is based on a DVD data storage optical pick-up unit (OPU). With a spinning mechanism, this device can simultaneously measure surface topography, mechanical deflections and resonance frequencies of several microfabricated beams at a high speed. In biochemical sensing applications, the OPU can measure bending changes of functionalized microcantilevers, providing a statistically robust and label-free bio-detection analysis of multiple compounds. The signal-to-noise ratio (S/N) is demonstrated from statistical measurements as 1.2 with arginine detection at 750 nM concentration. Practically, the OPU can measure up to 480 individual cantilever sensors per second with nanometer resolution. The opto-mechanical optimization of the device design and settings for biochemical detection are described.
Journal of Micromechanics and Microengineering, 2013, Vol 23, Issue 4