Bretlau, Claus1; Sørensen, Martin Kryspin3; Vedersoe, Anne-Lise Zimling4; Rasmussen, Lars Simon2; Gätke, Mona Ring1
1 Anaesthesiology, Herlev, Herlev and Gentofte Hospital, The Capital Region of Denmark2 Anæstesi- og operationsklinikken HOC, HovedOrtoCentret Rigshospitalet, Rigshospitalet, The Capital Region of Denmark3 Neuroanæstesiologisk Klinik, Neurocentret, Rigshospitalet, The Capital Region of Denmark4 unknown
Succinylcholine is usually metabolized quickly by the butyrylcholinesterase enzyme (BChE) but genetic variants of BChE may prolong the duration of action. The Kalow (K) variant is the most common mutation in the butyrylcholinesterase gene (BCHE), being present in 25% of Caucasians. The significance of the K-variant for the duration of action of succinylcholine has not been well studied. Our hypothesis was that the duration of action of succinylcholine would be prolonged in patients heterozygous for the K-variant genotype compared with the normal genotype (wild-type).
Anesthesia and Analgesia, 2013, Vol 116, Issue 3, p. 596-601