Andersen, Peter E.4; Thrane, Lars1; Yura, Harold T.5; Tycho, Andreas1; Jørgensen, Thomas Martini6
Valery V. Tuchin
1 Department of Photonics Engineering, Technical University of Denmark2 Diode Lasers and LED Systems, Department of Photonics Engineering, Technical University of Denmark3 Teraherts Technologies and Biophotonics, Department of Photonics Engineering, Technical University of Denmark4 Copenhagen Center for Health Technology, Center, Technical University of Denmark5 The Aerospace Corporation6 Centre for oil and gas – DTU, Center, Technical University of Denmark
Analytical and numerical models for describing and understanding the light propagation in samples imaged by optical coherence tomography (OCT) systems are presented. An analytical model for calculating the OCT signal based on the extended Huygens-Fresnel principle valid both for the single- and multiple-scattering regimes is derived. An advanced Monte Carlo model for calculating the OCT signal is also derived, and the validity of this model is shown through a mathematical proof based on the extended Huygens-Fresnel principle. From the analytical model, an algorithm for enhancing OCT images is developed, the so-called true-reflection algorithm in which the OCT signal may be corrected for the attenuation caused by scattering. The algorithm is verified experimentally and by using the Monte Carlo model as a numerical tissue phantom. Applications of extraction of optical properties from tissue are discussed. Finally, the Wigner phase-space distribution function is derived in a closed-form solution, which may have applications in OCT.
Handbook of Coherent-domain Optical Methods: Biomedical Diagnostics, Environmental Monitoring, and Materials Science, 2013, p. 743-798