While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.
Thorax, 2013, Vol 68, Issue 3, p. 288-9
Adult; Alcohol Drinking; BCG Vaccine; Case-Control Studies; Cicatrix; Confidence Intervals; HIV Infections; HIV Seronegativity; Humans; Logistic Models; Multivariate Analysis; Odds Ratio; Risk Factors; Smoking; Tanzania; Tuberculosis, Pulmonary; Letter