Faurholt-Jepsen, Daniel9; Range, Nyagosya2; PrayGod, George3; Jeremiah, Kidola3; Faurholt-Jepsen, Maria10; Aabye, Martine G5; Grewal, Harleen M S6; Changalucha, John3; Witte, Daniel R7; Andersen, Aase B8; Friis, Henrik9
1 Paediatric and International Nutrition, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet2 Muhibili Research Centre, National Institute for Medical Research, Dar es Salaam3 Mwanza Research Centre, National Institute of Medical Research, Tanzania.4 Paediatric Nutrition and International Nutrition, Department of Human Nutrition, Faculty of Life Sciences, Københavns Universitet5 Clinical Research Centre, University of Copenhagen, Hvidovre Hospital, Hvidovre6 Section of Microbiology and Immunology, University of Bergen & Department of Microbiology and Immunology, The Gade Institute, Haukeland University Hospital, Bergen7 Steno Diabetes Center, Gentofte8 Department of Infectious Diseases, Odense University Hospital9 Paediatric and International Nutrition, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet10 Paediatric Nutrition and International Nutrition, Department of Human Nutrition, Faculty of Life Sciences, Københavns Universitet
a matched case-control study in Mwanza, Tanzania
While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.