bi-directional Mendelian randomization analysis of multiple cohorts
Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis.
Plos Medicine, 2013, Vol 10, Issue 2
Adult; Aged; Aged, 80 and over; Biological Markers; Body Mass Index; Europe; European Continental Ancestry Group; Evidence-Based Medicine; Female; Genetic Predisposition to Disease; Humans; Linear Models; Male; Mendelian Randomization Analysis; Middle Aged; Multivariate Analysis; North America; Obesity; Phenotype; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Vitamin D; Vitamin D Deficiency; Journal Article; Meta-Analysis; Multicenter Study; Research Support, Non-U.S. Gov't