Møller, Rikke Steensbjerre4; YG, Weber,2; Klitten, Laura Line3; H, Trucks,2; H, Muhle,2; WS, Kunz,2; HC, Mefford,2; A, Franke,2; M, Kautza,2; P, Wolf,2; D, Dennig,2; S, Schreiber,2; IM, Rückert,2; HE, Wichmann,2; JP, Ernst,2; C, Schurmann,2; HJ, Grabe,2; N, Tommerup,2; U, Stephani,2; H, Lerche,2; Hjalgrim, Helle4; I, Helbig,2; T, Sander,2
1 Danish Epilepsy Centre, Institute of Regional Health Research, Det Sundhedsvidenskabelige Fakultet, SDU2 unknown3 Afdeling IV4 Danish Epilepsy Centre, Institute of Regional Health Research, Det Sundhedsvidenskabelige Fakultet, SDU
Neurexins are neuronal adhesion molecules located in the presynaptic terminal, where they interact with postsynaptic neuroligins to form a transsynaptic complex required for efficient neurotransmission in the brain. Recently, deletions and point mutations of the neurexin 1 (NRXN1) gene have been associated with a broad spectrum of neuropsychiatric disorders. This study aimed to investigate if NRXN1 deletions also increase the risk of idiopathic generalized epilepsies (IGEs).