1 Anaesthesiology, Department of - Juliane Marie Centre, Juliane Marie Centre, Rigshospitalet, The Capital Region of Denmark2 Cochrane ACE (Anaesthesia, Critical and Emergency Care), Anaesthesiology, Herlev, Herlev and Gentofte Hospital, The Capital Region of Denmark3 unknown
Rapid molecular diagnostics for bloodstream infection - a new frontier?
ABSTRACT: Among critically ill patients, the diagnosis of bloodstream infection poses a major challenge. Current standard bacterial identification based on blood culture platforms is intrinsically time-consuming and slow. The continuous evolvement of molecular techniques has the potential of providing a faster, more sensitive and direct identification of causative pathogens without prior need for cultivation. This may ultimately impact clinical decision-making and antimicrobial treatment. This review summarises the currently available technologies, their strengths and limitations and the obstacles that have to be overcome in order to develop a satisfactory bedside point-of-care diagnostic tool for detection of bloodstream infection.
Critical Care (online Edition), 2012, Vol 16, Issue 3
Journal Article; Research Support, Non-U.S. Gov't; Review