1 Ecology and Evolution, Department of Biology, Faculty of Science, Københavns Universitet2 Section for Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet3 Commonwealth Scientific and Industrial Research Organization (CSIRO)4 Chinese Academy of Sciences5 BGI-Shenzhen6 Naval Medical Research Center7 Uniformed Services University of the Health Sciences8 Department of Biology, Faculty of Science, Københavns Universitet9 Ecology and Evolution, Department of Biology, Faculty of Science, Københavns Universitet10 Naval Medical Research Center11 Uniformed Services University of the Health Sciences12 Department of Biology, Faculty of Science, Københavns Universitet
Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor-¿B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.
Science (new York, N.y.), 2013, Vol 339, Issue 6118