Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects

Jens Holmer-Jensen; Lene Sundahl Mortensen; Arne Astrup; Michael de Vrese; Jens Juul Holst; Claus Thomsen; Kjeld Hermansen

doi:10.1016/j.nutres.2012.11.004

Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects

Authors:

Holmer-Jensen, Jens ;
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Department of Endocrinology and Metabolism, MEA, Aarhus University Hospital, THG, Aarhus
Mortensen, Lene Sundahl ;
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Department of Endocrinology and Metabolism, MEA, Aarhus University Hospital, THG, Aarhus
Astrup, Arne ;
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0000-0001-8968-8996
Department of Nutrition, Exercise and Sports, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
de Vrese, Michael ;
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Federal Research Institute for Nutrion and Food, Institute for Physiology and Biochemistry of Nutrition, Kiel
Holst, Jens Juul ;
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Section of Endocrinology Research, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
Thomsen, Claus ;
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Department of Endocrinology and Metabolism, MEA, Aarhus University Hospital, THG, Aarhus
Hermansen, Kjeld
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Department of Endocrinology and Metabolism, MEA, Aarhus University Hospital, THG, Aarhus

DOI:

10.1016/j.nutres.2012.11.004

Abstract:

Non-fasting triglyceridemia is much closer associated to cardiovascular risk compared to fasting triglyceridemia. We hypothesized that there would be acute differential effects of four common dietary proteins (cod protein, whey isolate, gluten, and casein) on postprandial lipemia in obese non-diabetic subjects. To test the hypothesis we conducted a randomized, acute clinical intervention study with crossover design. We supplemented a fat rich mixed meal with one of four dietary proteins i.e. cod protein, whey protein, gluten or casein. Eleven obese non-diabetic subjects (age: 40-68, body mass index: 30.3-42.0 kg/m(2)) participated and blood samples were drawn in the 8-h postprandial period. Supplementation of a fat rich mixed meal with whey protein caused lower postprandial lipemia (P = .048) compared to supplementation with cod protein and gluten. This was primarily due to lower triglyceride concentration in the chylomicron rich fraction (P = .0293). Thus, we have demonstrated acute differential effects on postprandial metabolism of four dietary proteins supplemented to a fat rich mixed meal in obese non-diabetic subjects. Supplementation with whey protein caused lower postprandial lipemia compared to supplementation with cod and gluten. As postprandial lipemia is closely correlated to cardiovascular disease, long-term dietary supplementation with whey protein may prove beneficial in preventing cardiovascular disease in obese non-diabetic subjects.

Type:

Journal article

Language:

English

Published in:

Nutrition Research, 2013, Vol 33, Issue 1, p. 34-40

Main Research Area:

Science/technology

Publication Status:

Published

Review type:

Peer Review

Submission year:

2013

Scientific Level:

Scientific

ID:

235264859

Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects

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