1 Environmental Medicine, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU2 Divison of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, National Institute of Environmental Health Sciences, North Carolina3 INSERM UMR-S 747, Universite Descartes, Paris4 Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland5 Institute of Developmental Sciences, University of Southhampton, Southhampton General Hospital, Hampshire6 Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, National Institute of Environmental Health Sciences, North Carolina7 Environmental Medicine, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU
Fetal and early postnatal development constitutes the most vulnerable time period of human life in regard to adverse effects of environmental hazards. Subtle effects during development can lead to functional deficits and increased disease risk later in life. The hypothesis stating that environmental exposures leads to altered programming and, thereby, to increased susceptibility to disease or dysfunction later in life has garnered much support from both experimental and epidemiological studies. Similar observations have been made on the long-term impact of nutritional unbalance during early development. In an effort to bridge the fields of nutritional and environmental developmental toxicity, the Society of Toxicology sponsored this work. This report summarizes novel findings in developmental toxicity as reported by select invited experts and meeting attendees. Recommendations for the application and improvement of current and future research efforts are also presented.
Toxicological Sciences, 2013, Vol 131, Issue 2, p. 343-50
developmental origins of health and disease; developmental toxicity; early-life exposure