Effects of tobacco smoking in pregnancy on offspring intelligence at the age of 5

Hanne-Lise Falgreen Eriksen; Ulrik Schiøler Kesmodel; Theresa Wimberley; Mette Underbjerg; Tina Røndrup Kilburn; Erik Lykke Mortensen

doi:10.1155/2012/945196

Effects of tobacco smoking in pregnancy on offspring intelligence at the age of 5

Authors:

Falgreen Eriksen, Hanne-Lise ;
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Department of Public Health, Health, Aarhus University
Kesmodel, Ulrik Schiøler ;
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Department of Clinical Medicine - Department of Obstetrics and Gynaecology, Department of Clinical Medicine, Health, Aarhus University
Wimberley, Theresa ;
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0000-0002-5011-5493
Department of Economics and Business Economics, Aarhus BSS, Aarhus University
Underbjerg, Mette ;
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Institute of Epidemiology and Social Medicine, Faculty of Health Sciences, Aarhus University, Aarhus University
Kilburn, Tina Røndrup ;
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0000-0002-0987-6514
Department of Clinical Medicine - Psychiatric Hospital for Children and Adolescents, Department of Clinical Medicine, Health, Aarhus University
Mortensen, Erik Lykke
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unknown

DOI:

10.1155/2012/945196

Abstract:

The aim of the study was to examine the effects of tobacco smoking in pregnancy on children's IQ at the age of 5. A prospective follow-up study was conducted on 1,782 women, and their offspring were sampled from the Danish National Birth Cohort. At 5 years of age, the children were tested with the Wechsler Preschool and Primary Scale of Intelligence-Revised. Parental education, maternal IQ, maternal alcohol consumption in pregnancy, the sex and age of the child, and tester were considered core confounders, but the full model also controlled for prenatal paternal smoking, maternal age and Bodymass Mass Index, parity, family/home environment, postnatal parental smoking, breast feeding, the child's health status, and indicators for hearing and vision impairments. Unadjusted analyses showed a statistically significant decrement of 4 points on full-scale IQ (FSIQ) associated with smoking 10+ cigarettes per day compared to nonsmoking. After adjustment for potential confounders, no significant effects of prenatal exposure to tobacco smoking were found. Considering the indisputable teratogenic effects of tobacco smoking, these findings should be interpreted with caution. Still, the results may indicate that previous studies that failed to control for important confounders, particularly maternal intelligence, may be subject to substantial residual confounding.

Type:

Journal article

Language:

English

Published in:

Journal of Pregnancy, 2012, Vol 2012

Keywords:

Adult; Child, Preschool; Female; Follow-Up Studies; Humans; Intelligence; Intelligence Tests; Logistic Models; Maternal Behavior; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Smoking; Surveys and Questionnaires; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Main Research Area:

Medical science

Publication Status:

Published

Review type:

Peer Review

Submission year:

2013

Scientific Level:

Scientific

ID:

234984175

Effects of tobacco smoking in pregnancy on offspring intelligence at the age of 5

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