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Birth weight in offspring and leukaemia risk in parents-A nation-wide register-based cohort study from Denmark

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Authors:
  • Marklund, Maria ;
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    unknown
  • Rostgaard, Klaus ;
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    unknown
  • Hjalgrim, Lisa ;
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    unknown
  • Schmiegelow, Kjeld ;
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    Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Hjalgrim, Henrik
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    unknown
DOI:
10.1016/j.leukres.2012.10.006
Abstract:
Spurred by previous observations we assessed the relationship between offspring birth weight and parental leukaemia risk in a register-based investigation including 2.4 million parents of 2 million Danish children. Regardless of analytical approach, offspring birth weight was not associated with parental risk of leukaemia overall or of leukaemia subtypes except for a twofold increased acute lymphatic leukaemia risk in fathers of high birth weight offspring and an increasing paternal risk of chronic myeloid leukaemia with increasing offspring birth weight. These may both be chance findings. Our investigation indicates that offspring birth weight is not strongly associated with parental leukaemia risk.
Type:
Journal article
Language:
English
Published in:
Leukemia Research, 2013, Vol 37, Issue 2, p. 129-33
Keywords:
Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
234803202

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