In patients with traumatic brain injury as well as stroke, impaired cerebral oxidative energy metabolism may be an important factor contributing to the ultimate degree of tissue damage. We hypothesize that mitochondrial dysfunction can be diagnosed bedside by comparing the simultaneous changes in brain tissue oxygen tension (PbtO(2)) and cerebral cytoplasmatic redox state. The study describes cerebral energy metabolism during mitochondrial dysfunction induced by sevoflurane in piglets.
Acta Anaesthesiologica Scandinavica, 2013, Vol 57, Issue 2, p. 229-35
Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blood Pressure; Body Temperature; Brain Chemistry; Cytoplasm; Energy Metabolism; Female; Glucose; Intracranial Pressure; Lactic Acid; Methyl Ethers; Mitochondrial Diseases; Oxidation-Reduction; Oxygen Consumption; Pyruvic Acid; Swine; Journal Article; Research Support, Non-U.S. Gov't