relation to decreased mitochondrial function and glucose intolerance
Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9).
American College of Cardiology. Journal, 2013, Vol 61, Issue 1, p. 44-53
Journal Article; Research Support, Non-U.S. Gov't; Blood Glucose; Case-Control Studies; Cell Respiration; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Glucose Intolerance; Glucose Tolerance Test; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Male; Middle Aged; Mitochondria, Muscle; Muscle Fibers, Skeletal; Muscle, Skeletal; Oxidative Phosphorylation; Simvastatin; Ubiquinone