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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

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Authors:
  • Horikoshi, Momoko ;
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    unknown
  • Yaghootkar, Hanieh ;
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    unknown
  • Mook-Kanamori, Dennis O ;
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  • Sovio, Ulla ;
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  • Taal, H Rob ;
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  • Hennig, Branwen J ;
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  • Bradfield, Jonathan P ;
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  • St Pourcain, Beate ;
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  • Evans, David M ;
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  • Charoen, Pimphen ;
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  • Kaakinen, Marika ;
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  • Cousminer, Diana L ;
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  • Lehtimäki, Terho ;
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  • Kreiner-Møller, Eskil ;
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    Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Warrington, Nicole M ;
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  • Bustamante, Mariona ;
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  • Feenstra, Bjarke ;
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  • Berry, Diane J ;
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  • Thiering, Elisabeth ;
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  • Pfab, Thiemo ;
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  • Barton, Sheila J ;
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  • Shields, Beverley M ;
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  • Kerkhof, Marjan ;
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  • van Leeuwen, Elisabeth M ;
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  • Fulford, Anthony J ;
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  • Kutalik, Zoltán ;
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  • Zhao, Jing Hua ;
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  • den Hoed, Marcel ;
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  • Mahajan, Anubha ;
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  • Lindi, Virpi ;
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  • Goh, Liang-Kee ;
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  • Hottenga, Jouke-Jan ;
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  • Wu, Ying ;
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  • Raitakari, Olli T ;
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  • Harder, Marie N ;
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    Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet
  • Meirhaeghe, Aline ;
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    unknown
  • Ntalla, Ioanna ;
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  • Salem, Rany M ;
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  • Jameson, Karen A ;
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  • Zhou, Kaixin ;
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  • Hansen, Torben ;
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    Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet
  • Jørgensen, Torben ;
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    Department of Public Health, Department of Public Health, Faculty of Health and Medical Sciences, Københavns Universitet
  • Kilpeläinen, Tuomas O ;
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    Endocrinology and Metabolism, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
  • Pedersen, Louise ;
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    Clinical an Experimental Nutrition, Department of Human Nutrition, Faculty of Life Sciences, Københavns Universitet
  • Vaag, Allan ;
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    Section of Orthopaedics and Internal Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Vissing, Nadja Hawwa ;
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    Department of Psychology, Study Council, Department of Psychology, Faculty of Social Sciences, Københavns Universitet
  • Witte, Daniel R ;
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    Graduate School of Health and Medical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
  • Pedersen, Oluf ;
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    Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet
  • Bønnelykke, Klaus ;
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    Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Bisgaard, Hans
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    Orcid logo0000-0003-4131-7592
    Section of Gynaecology, Obstetrics and Paediatrics, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
DOI:
10.1038/ng.2477
Abstract:
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Type:
Journal article
Language:
English
Published in:
Nature Genetics, 2013, Vol 45, Issue 1, p. 76-82
Keywords:
Adult; Birth Weight; Blood Pressure; Body Height; Diabetes Mellitus, Type 2; Female; Fetal Development; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Infant, Newborn; Male; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
234520303

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