New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
- Authors:
-
- Horikoshi, Momoko ;
- Yaghootkar, Hanieh ;
- Mook-Kanamori, Dennis O ;
- Sovio, Ulla ;
- Taal, H Rob ;
- Hennig, Branwen J ;
- Bradfield, Jonathan P ;
- St Pourcain, Beate ;
- Evans, David M ;
- Charoen, Pimphen ;
- Kaakinen, Marika ;
- Cousminer, Diana L ;
- Lehtimäki, Terho ;
- Kreiner-Møller, Eskil ;
- Warrington, Nicole M ;
- Bustamante, Mariona ;
- Feenstra, Bjarke ;
- Berry, Diane J ;
- Thiering, Elisabeth ;
- Pfab, Thiemo ;
- Barton, Sheila J ;
- Shields, Beverley M ;
- Kerkhof, Marjan ;
- van Leeuwen, Elisabeth M ;
- Fulford, Anthony J ;
- Kutalik, Zoltán ;
- Zhao, Jing Hua ;
- den Hoed, Marcel ;
- Mahajan, Anubha ;
- Lindi, Virpi ;
- Goh, Liang-Kee ;
- Hottenga, Jouke-Jan ;
- Wu, Ying ;
- Raitakari, Olli T ;
- Harder, Marie N ;
- Meirhaeghe, Aline ;
- Ntalla, Ioanna ;
- Salem, Rany M ;
- Jameson, Karen A ;
- Zhou, Kaixin ;
- Monies, Dorota M ;
- Lagou, Vasiliki ;
- Kirin, Mirna ;
- Heikkinen, Jani ;
- Adair, Linda S ;
- Alkuraya, Fowzan S ;
- Al-Odaib, Ali ;
- Amouyel, Philippe ;
- Andersson, Ehm Astrid ;
- Bennett, Amanda J ;
- Blakemore, Alexandra I F ;
- Buxton, Jessica L ;
- Dallongeville, Jean ;
- Das, Shikta ;
- de Geus, Eco J C ;
- Estivill, Xavier ;
- Flexeder, Claudia ;
- Froguel, Philippe ;
- Geller, Frank ;
- Godfrey, Keith M ;
- Gottrand, Frédéric ;
- Groves, Christopher J ;
- Hansen, Torben ;
- Hirschhorn, Joel N ;
- Hofman, Albert ;
- Hollegaard, Mads V ;
- Hougaard, David M ;
- Hyppönen, Elina ;
- Inskip, Hazel M ;
- Isaacs, Aaron ;
- Jørgensen, Torben ;
- Kanaka-Gantenbein, Christina ;
- Kemp, John P ;
- Kiess, Wieland ;
- Kilpeläinen, Tuomas O ;
- Klopp, Norman ;
- Knight, Bridget A ;
- Kuzawa, Christopher W ;
- McMahon, George ;
- Newnham, John P ;
- Niinikoski, Harri ;
- Oostra, Ben A ;
- Pedersen, Louise ;
- Postma, Dirkje S ;
- Ring, Susan M ;
- Rivadeneira, Fernando ;
- Robertson, Neil R ;
- Sebert, Sylvain ;
- Simell, Olli ;
- Slowinski, Torsten ;
- Tiesler, Carla M T ;
- Tönjes, Anke ;
- Vaag, Allan ;
- Viikari, Jorma S ;
- Vink, Jacqueline M ;
- Vissing, Nadja Hawwa ;
- Wareham, Nicholas J ;
- Willemsen, Gonneke ;
- Witte, Daniel ;
- Zhang, Haitao ;
- Zhao, Jianhua ;
- Wilson, James F ;
- Stumvoll, Michael ;
- Prentice, Andrew M ;
- Meyer, Brian F ;
- Pearson, Ewan R ;
- Boreham, Colin A G ;
- Cooper, Cyrus ;
- Gillman, Matthew W ;
- Dedoussis, George V ;
- Moreno, Luis A ;
- Pedersen, Oluf ;
- Saarinen, Maiju ;
- Mohlke, Karen L ;
- Boomsma, Dorret I ;
- Saw, Seang-Mei ;
- Lakka, Timo A ;
- Körner, Antje ;
- Loos, Ruth J F ;
- Ong, Ken K ;
- Vollenweider, Peter ;
- van Duijn, Cornelia M ;
- Koppelman, Gerard H ;
- Hattersley, Andrew T ;
- Holloway, John W ;
- Hocher, Berthold ;
- Heinrich, Joachim ;
- Power, Chris ;
- Melbye, Mads ;
- Guxens, Mònica ;
- Pennell, Craig E ;
- Bønnelykke, Klaus ;
- Bisgaard, Hans ;
- Eriksson, Johan G ;
- Widén, Elisabeth ;
- Hakonarson, Hakon ;
- Uitterlinden, André G ;
- Pouta, Anneli ;
- Lawlor, Debbie A ;
- Smith, George Davey ;
- Frayling, Timothy M ;
- McCarthy, Mark I ;
- Grant, Struan F A ;
- Jaddoe, Vincent W V ;
- Jarvelin, Marjo-Riitta ;
- Timpson, Nicholas J ;
- Prokopenko, Inga ;
- Freathy, Rachel M
- DOI:
- 10.1038/ng.2477
- Abstract:
- Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
- Type:
- Journal article
- Language:
- English
- Published in:
- Nature Genetics, 2013, Vol 45, Issue 1, p. 76-82
- Keywords:
- Adult; Birth Weight; Blood Pressure; Body Height; Diabetes Mellitus, Type 2; Female; Fetal Development; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Infant, Newborn; Male; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2013
- Scientific Level:
- Scientific
- ID:
- 234520303
