New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
- Authors:
-
- Horikoshi, Momoko ;
- Yaghootkar, Hanieh ;
- Mook-Kanamori, Dennis O ;
- Sovio, Ulla ;
- Taal, H Rob ;
- Hennig, Branwen J ;
- Bradfield, Jonathan P ;
- St Pourcain, Beate ;
- Evans, David M ;
- Charoen, Pimphen ;
- Kaakinen, Marika ;
- Cousminer, Diana L ;
- Lehtimäki, Terho ;
- Kreiner-Møller, Eskil ;
- Warrington, Nicole M ;
- Bustamante, Mariona ;
- Feenstra, Bjarke ;
- Berry, Diane J ;
- Thiering, Elisabeth ;
- Pfab, Thiemo ;
- Barton, Sheila J ;
- Shields, Beverley M ;
- Kerkhof, Marjan ;
- van Leeuwen, Elisabeth M ;
- Fulford, Anthony J ;
- Kutalik, Zoltán ;
- Zhao, Jing Hua ;
- den Hoed, Marcel ;
- Mahajan, Anubha ;
- Lindi, Virpi ;
- Goh, Liang-Kee ;
- Hottenga, Jouke-Jan ;
- Wu, Ying ;
- Raitakari, Olli T ;
- Harder, Marie N ;
- Meirhaeghe, Aline ;
- Ntalla, Ioanna ;
- Salem, Rany M ;
- Jameson, Karen A ;
- Zhou, Kaixin ;
-
Hansen, Torben
;
Close
0000-0001-8748-3831
Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet - Jørgensen, Torben ;
-
Kilpeläinen, Tuomas O
;
Close0000-0002-8349-3028
Endocrinology and Metabolism, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet - Pedersen, Louise ;
- Vaag, Allan ;
- Vissing, Nadja Hawwa ;
- Witte, Daniel R ;
-
Pedersen, Oluf
;
Close0000-0002-3321-3972
Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet - Bønnelykke, Klaus ;
-
Bisgaard, Hans
Close0000-0003-4131-7592
Section of Gynaecology, Obstetrics and Paediatrics, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
- DOI:
- 10.1038/ng.2477
- Abstract:
- Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
- Type:
- Journal article
- Language:
- English
- Published in:
- Nature Genetics, 2013, Vol 45, Issue 1, p. 76-82
- Keywords:
- Adult; Birth Weight; Blood Pressure; Body Height; Diabetes Mellitus, Type 2; Female; Fetal Development; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Infant, Newborn; Male; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2013
- Scientific Level:
- Scientific
- ID:
- 234520303
