1 Department of Clinical Medicine - The Department of General Psychiatry, Department of Clinical Medicine, Health, Aarhus University2 Neuro- og Sansefag3 Institut for Psykologi4 Institut for Byggeri og Anlæg5 unknown6 LUKKET: Klinikudvalget Københavns Amt7 Department of Clinical Medicine - Afdeling for Depression og Angst, afd. Q, Department of Clinical Medicine, Health, Aarhus University8 Department of Clinical Medicine - Afdeling for Depression og Angst, afd. Q, Department of Clinical Medicine, Health, Aarhus University
During recent decades, the field of treatment of schizophrenia has lacked empirical, systematic outcome studies that support psychodynamic psychotherapy as an evidence-based intervention for patients with schizophrenia. The Danish schizophrenia project (DNS) compared psychodynamic psychotherapy for psychosis with standard treatment in patients with a first-episode schizophrenia spectrum disorder. The study was designed as a prospective, comparative, longitudinal multi-site investigation of consecutively referred patients who were included during two years. The patients were treated with either manualized individual supportive psychodynamic psychotherapy (SPP) in addition to treatment as usual or with treatment as usual alone (TaU). Symptoms and functional outcomes were measured using the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning scale (GAF). The study included 269 consecutively admitted patients, age 18-35, of whom 79% remained in the study after two years. The intervention group improved significantly on measures of both PANSS and GAF scores, with large effect sizes at two years follow-up after inclusion. Further, improvement on GAF(function) (p = 0.000) and GAF(symptom) (p = 0.010) significantly favored SPP in combination with TaU over TaU alone. In spite of limitations, this study speaks in favor of including supportive psychodynamic psychotherapy in the treatment for patients with schizophrenic first-episode psychoses.