Wang, P3; Holst, Claus16; Wodzig, W K W H4; Andersen, Malene Rohr16; Astrup, Arne17; van Baak, M A3; Larsen, Thomas Meinert18; Jebb, S A7; Kafatos, A8; Pfeiffer, A F H9; Martinez, J A10; Handjieva-Darlenska, T11; Kunesova, M12; Vigurie, N13; Langin, D14; Saris, W H M3; Mariman, E C M3; Diogenes Consortium15
1 Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet2 Prevention and Treatment of Obesity and Appetite and Energy Metabolism, Department of Human Nutrition, Faculty of Life Sciences, Københavns Universitet3 Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastrcht University Medical Centre, Maastricht4 Department of Clinical Chemistry, Maastricht University Medical Centre, Maastricht5 Department of Nutrition, Exercise and Sports, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet6 Obesity Research, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet7 MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge8 Department of Social Medicine, Preventive Medicine and Nutrition Clinic, University of Crete, Crete9 Department of Clinical Nutrition, German Institute of Human Nutrition, Nutheal & Department of Endocrinology, Diabetes and Nutrition, Charité Universitätsmedizin Berlin, Berlin10 Department of Physiology and Nutrition, University of Navarra, Pamplona11 Department of Nutrition, Dietetics and Metabolic Diseases, National Multiprofile Transport Hospital, Sofia12 Obesity Management Centre, Institute of Endocrinology, Prague13 Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, University of Toulouse, Toulouse14 University of Toulouse15 EU contract no. FOOD-CT-2005-51394616 Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet17 Department of Nutrition, Exercise and Sports, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet18 Obesity Research, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
BACKGROUND: Circulating angiotensin-converting enzyme (ACE) was identified as a predictor of weight loss maintenance in overweight/obese women of the Diogenes project. OBJECTIVE: To investigate whether ACE acted also as a predictor in men of the Diogenes study and to compare it with that in women. DESIGN: Subjects, who lost ¿8% of body weight induced by low-caloric diet in an 8-week weight loss period, were assigned to weight loss maintenance with dietary intervention for 6 months. SUBJECTS: 125 overweight/obese healthy men from eight European countries who completed whole intervention. MEASUREMENTS: Concentrations and activity of serum ACE at baseline and after the 8-week weight loss, in addition to anthropometric and physiological parameters. RESULTS: Serum ACE concentration decreased by 11.3±10.6% during the weight loss period in men. A greater reduction is associated with less body weight regain during the maintenance period (r=0.227, P=0.012). ACE change was able to predict a weight regain ¿20% after 6 months, with an odds ratio of 1.59 (95% confidence interval (CI): 1.09-2.33, P=0.016) for every 10% reduction, which was independent of body mass index and weight loss. The prediction power was weaker in men than in women, but without a significant sex difference (P=0.137). In pooled subjects (N=218), the odds ratio was 1.96 (95% CI: 1.46-2.64, P<0.001). CONCLUSIONS: A greater reduction of ACE during weight loss is favorable for weight maintenance in both men and women. This can offer useful information for personalized advice to improve weight loss maintenance. It also confirms the role of ACE in the metabolic pathways of weight regulation.
International Journal of Obesity, 2012, Vol 36, Issue 12, p. 1545-1551