Bagger, Frederik Otzen3; Rapin, Nicolas3; Theilgaard-Mönch, Kim3; Kaczkowski, Bogumil3; Thoren, Lina A.3; Jendholm, Johan3; Winther, Ole4; Porse, Bo Torben3
1 Department of Applied Mathematics and Computer Science, Technical University of Denmark2 Department of Informatics and Mathematical Modeling, Technical University of Denmark3 University of Copenhagen4 Department of Applied Electronics, Technical University of Denmark
a database of mRNA expression profiles in normal and malignant haematopoiesis
The HemaExplorer (http://servers.binf.ku.dk/hemaexplorer) is a curated database of processed mRNA Gene expression profiles (GEPs) that provides an easy display of gene expression in haematopoietic cells. HemaExplorer contains GEPs derived from mouse/human haematopoietic stem and progenitor cells as well as from more differentiated cell types. Moreover, data from distinct subtypes of human acute myeloid leukemia is included in the database allowing researchers to directly compare gene expression of leukemic cells with those of their closest normal counterpart. Normalization and batch correction lead to full integrity of the data in the database. The HemaExplorer has comprehensive visualization interface that can make it useful as a daily tool for biologists and cancer researchers to assess the expression patterns of genes encountered in research or literature. HemaExplorer is relevant for all research within the fields of leukemia, immunology, cell differentiation and the biology of the haematopoietic system.