Introduction: drugs acting on the central nervous system (CNS) increase falls risk. Most data on CNS drugs and falls are in women/mixed-sex populations. This study assessed the relationship between CNS drugs and falls in men aged 60–75 years. Methods: a questionnaire was sent to randomly selected Danish men aged 60–75 years. Cross-sectional data on CNS drugs and falls in the previous year were available for 4,696 men. Logistic regression investigated the relationship between falls and CNS drugs. Results: the median age was 66.3 (IQR = 63.1–70.0) years; 21.7% were fallers. The following were associated with fallers (OR; 95% CI): opiates (2.4; 1.5–3.7), other analgesics (1.7; 1.4–2.1), antiepileptics (2.8; 1.5–5.1), antidepressants (2.8; 1.9–4.1) and anxiolytics/hypnotics (1.5; 0.9–2.6). Effects of opiates interacted strongly and significantly with age, with a marked association with falls in the older half of the subjects only. No significant associations were found between antipsychotics and fallers. Selective serotonin reuptake inhibitors and tricyclics were significantly associated with fallers (3.1; 2.0–5.0 and 2.2; 1.0–4.7, respectively). Conclusion: several CNS drug classes are associated with an approximately 2–3-fold increase risk of falls in men aged 60–75 years randomly selected from the population. Further longitudinal data are now required to confirm and further investigate the role of CNS drugs in falls causation in men.