Jernigan, Terry L1; Baaré, William F C1; Stiles, Joan2; Madsen, Kathrine Skak1
1 Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and research, Amager and Hvidovre Hospital, The Capital Region of Denmark2 unknown
structural imaging of dynamic neurodevelopmental processes
After birth, there is striking biological and functional development of the brain's fiber tracts as well as remodeling of cortical and subcortical structures. Behavioral development in children involves a complex and dynamic set of genetically guided processes by which neural structures interact constantly with the environment. This is a protracted process, beginning in the third week of gestation and continuing into early adulthood. Reviewed here are studies using structural imaging techniques, with a special focus on diffusion weighted imaging, describing age-related brain maturational changes in children and adolescents, as well as studies that link these changes to behavioral differences. Finally, we discuss evidence for effects on the brain of several factors that may play a role in mediating these brain-behavior associations in children, including genetic variation, behavioral interventions, and hormonal variation associated with puberty. At present longitudinal studies are few, and we do not yet know how variability in individual trajectories of biological development in specific neural systems map onto similar variability in behavioral trajectories.
Progress in Brain Research, 2011, Vol 189, p. 77-92
Journal Article; Research Support, Non-U.S. Gov't; Review; Aging; Behavior; Brain; Diffusion Magnetic Resonance Imaging; Humans; Morphogenesis; Puberty