Mangino, Massimo6; Hwang, Shih-Jen6; Spector, Timothy D6; Hunt, Steven C6; Kimura, Masayuki6; Fitzpatrick, Annette L6; Christiansen, Lene8; Petersen, Inge8; Elbers, Clara C6; Harris, Tamara6; Chen, Wei7; Srinivasan, Sathanur R6; Kark, Jeremy D6; Benetos, Athanase6; El Shamieh, Said6; Visvikis-Siest, Sophie6; Christensen, Kaare8; Berenson, Gerald S6; Valdes, Ana M6; Viñuela, Ana6; Garcia, Melissa6; Arnett, Donna K6; Broeckel, Ulrich6; Province, Michael A6; Pankow, James S6; Kammerer, Candace6; Liu, Yongmei6; Nalls, Michael6; Tishkoff, Sarah6; Thomas, Fridtjof6; Ziv, Elad6; Psaty, Bruce M6; Bis, Joshua C6; Rotter, Jerome I6; Taylor, Kent D6; Smith, Erin6; Schork, Nicholas J6; Levy, Daniel6; Aviv, Abraham6
1 Epidemiology, Biostatistics and Biodemography, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU2 Clinical Biochemistry, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU3 The Danish Twin Registry, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU4 Human Genetics, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU5 Danish Aging Research Center, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU6 unknown7 Department of Physics8 Epidemiology, Biostatistics and Biodemography, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU
Leukocyte telomere length (LTL) is associated with a number of common age-related diseases and is a heritable trait. Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated with the inter-individual LTL variation. We performed a meta-analysis of 9190 individuals from six independent GWAS and validated our findings in 2226 individuals from four additional studies. We confirmed previously reported associations with OBFC1 (rs9419958 P = 9.1 × 10(-11)) and with the telomerase RNA component TERC (rs1317082, P = 1.1 × 10(-8)). We also identified two novel genomic regions associated with LTL variation that map near a conserved telomere maintenance complex component 1 (CTC1; rs3027234, P = 3.6 × 10(-8)) on chromosome17p13.1 and zinc finger protein 676 (ZNF676; rs412658, P = 3.3 × 10(-8)) on 19p12. The minor allele of rs3027234 was associated with both shorter LTL and lower expression of CTC1. Our findings are consistent with the recent observations that point mutations in CTC1 cause short telomeres in both Arabidopsis and humans affected by a rare Mendelian syndrome. Overall, our results provide novel insights into the genetic architecture of inter-individual LTL variation in the general population.
Human Molecular Genetics, 2012, Vol 21, Issue 24, p. 5385-94