Kvist, Linus2; Giwercman, Yvonne Lundberg2; Jönsson, Bo A G2; Lindh, Christian H2; Bonde, Jens Peter3; Toft, Gunnar5; Strucinski, Pawel2; Pedersen, Henning Sloth4; Zvyezday, Valentyna2; Giwercman, Aleksander2
1 Department of Clinical Medicine - Occupational Medicine, Department of Clinical Medicine, Health, Aarhus University2 unknown3 Institut for Folkesundhedsvidenskab4 Miljømedicin5 Department of Clinical Medicine - Occupational Medicine, Department of Clinical Medicine, Health, Aarhus University
This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.