Jin, Guang2; Duggan, Michael3; Imam, Ayesha3; Demoya, Marc A3; Sillesen, Martin4; Hwabejire, John3; Jepsen, Cecilie H3; Liu, Baoling3; Mejaddam, Ali Y3; Lu, Jennifer3; Smith, William Michael3; Velmahos, George C3; Socrate, Simona3; Alam, Hasan B3
1 Anæstesi- og operationsklinikken HOC, HovedOrtoCentret Rigshospitalet, Rigshospitalet, The Capital Region of Denmark2 Brigham and Women's Hospital and Harvard Medical School3 unknown4 Kirurgisk Gastroenterologisk Klinik, Abdominal Centre, Rigshospitalet, The Capital Region of Denmark
We have previously demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival after hemorrhagic shock (HS), protect neurons from hypoxia-induced apoptosis, and attenuate the inflammatory response. We have also shown that administration of 6% hetastarch (Hextend [Hex]) after traumatic brain injury (TBI) decreases brain swelling, without affecting size of the lesion. This study was performed to determine whether addition of VPA to Hex would decrease the lesion size in a clinically relevant large animal model of TBI + HS.
Journal of Trauma and Acute Care Surgery, 2012, Vol 73, Issue 6, p. 1461-70
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Animals; Brain Injuries; Disease Models, Animal; Drug Therapy, Combination; Female; Hemodynamics; Hydroxyethyl Starch Derivatives; Inflammation; Isotonic Solutions; Resuscitation; Shock, Hemorrhagic; Swine; Valproic Acid