We have previously demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival after hemorrhagic shock (HS), protect neurons from hypoxia-induced apoptosis, and attenuate the inflammatory response. We have also shown that administration of 6% hetastarch (Hextend [Hex]) after traumatic brain injury (TBI) decreases brain swelling, without affecting size of the lesion. This study was performed to determine whether addition of VPA to Hex would decrease the lesion size in a clinically relevant large animal model of TBI + HS.
Journal of Trauma and Acute Care Surgery, 2012, Vol 73, Issue 6, p. 1461-70
Animals; Brain Injuries; Disease Models, Animal; Drug Therapy, Combination; Female; Hemodynamics; Hydroxyethyl Starch Derivatives; Inflammation; Isotonic Solutions; Resuscitation; Shock, Hemorrhagic; Swine; Valproic Acid; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.