Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression

Maarja-Liisa Nairismägi; Andrii Vislovukh; Q Meng; Leslie-Ann Largitte; Cornelia Beldiman; Ernst-Martin Füchtbauer; Annick Harel-Bellan; Irina Groisman

doi:10.1038/onc.2011.650

Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression

Authors:

Nairismägi, Maarja-Liisa ;
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Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Vislovukh, Andrii ;
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Department of Translation Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine
Meng, Q ;
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The Breast Department of the Third Affiliated Hospital of Harbin Medical University, Harbin 150040, China
Largitte, Leslie-Ann ;
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Laboratoire Epigenetique et Cancer, FRE 3239, Institut Andre Lwoff, Villejuif France
Beldiman, Cornelia ;
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Laboratoire Epigenetique et Cancer, FRE 3239, Institut Andre Lwoff, Villejuif France
Füchtbauer, Ernst-Martin ;
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Department of Molecular Biology and Genetics - Molecular Cell and Developmental Biology, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Harel-Bellan, Annick ;
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Laboratoire Epigenetique et Cancer, FRE 3239, Institut Andre Lwoff, Villejuif France
Groisman, Irina
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Laboratoire Epigenetique et Cancer, FRE 3239, Institut Andre Lwoff, Villejuif France

DOI:

10.1038/onc.2011.650

Abstract:

TWIST1 is a highly conserved basic helix-loop-helix transcription factor that promotes epithelial–mesenchymal transition (EMT). Its misregulation has been observed in various types of tumors. Using the MCF-10A-series of cell lines that recapitulate the early stages of breast cancer formation and EMT, we found TWIST1 to be upregulated during EMT and downregulated early in carcinogenesis. The TWIST1 3′UTR contains putative regulatory elements, including miRNA target sites and two cytoplasmic polyadenylation elements (CPE). We found that miR-580, CPEB1, and CPEB2 act as negative regulators of TWIST1 expression in a sequence-specific and additive/cooperative manner.

Type:

Journal article

Language:

English

Published in:

Oncogene, 2012, Vol 31, p. 4960-4966

Main Research Area:

Science/technology

Publication Status:

Published

Review type:

Peer Review

Submission year:

2012

Scientific Level:

Scientific

ID:

233037461

Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression

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