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Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression

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Authors:
  • Nairismägi, Maarja-Liisa ;
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    Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
  • Vislovukh, Andrii ;
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    Department of Translation Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine
  • Meng, Q ;
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    The Breast Department of the Third Affiliated Hospital of Harbin Medical University, Harbin 150040, China
  • Largitte, Leslie-Ann ;
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    Laboratoire Epigenetique et Cancer, FRE 3239, Institut Andre Lwoff, Villejuif France
  • Beldiman, Cornelia ;
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    Laboratoire Epigenetique et Cancer, FRE 3239, Institut Andre Lwoff, Villejuif France
  • Füchtbauer, Ernst-Martin ;
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    Department of Molecular Biology and Genetics - Molecular Cell and Developmental Biology, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
  • Harel-Bellan, Annick ;
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    Laboratoire Epigenetique et Cancer, FRE 3239, Institut Andre Lwoff, Villejuif France
  • Groisman, Irina
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    Laboratoire Epigenetique et Cancer, FRE 3239, Institut Andre Lwoff, Villejuif France
DOI:
10.1038/onc.2011.650
Abstract:
TWIST1 is a highly conserved basic helix-loop-helix transcription factor that promotes epithelial–mesenchymal transition (EMT). Its misregulation has been observed in various types of tumors. Using the MCF-10A-series of cell lines that recapitulate the early stages of breast cancer formation and EMT, we found TWIST1 to be upregulated during EMT and downregulated early in carcinogenesis. The TWIST1 3′UTR contains putative regulatory elements, including miRNA target sites and two cytoplasmic polyadenylation elements (CPE). We found that miR-580, CPEB1, and CPEB2 act as negative regulators of TWIST1 expression in a sequence-specific and additive/cooperative manner.
Type:
Journal article
Language:
English
Published in:
Oncogene, 2012, Vol 31, p. 4960-4966
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2012
Scientific Level:
Scientific
ID:
233037461

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