The effect of triaging women with atypical squamous cells of undetermined significance (ASC-US) with human papillomavirus (HPV) DNA testing has been well documented. New tests detecting HPV E6/E7 mRNA are emerging, claiming to be more specific for detecting high-grade disease. We evaluated the clinical performance of two HPV tests: the Linear Array HPV genotyping test (LA) detecting HPV DNA from 37 oncogenic and non-oncogenic HPV types and the Aptima HPV assay detecting E6/E7 mRNA from 14 oncogenic HPV types.
Cytopathology, 2012, Vol 23, Issue 6, p. 389-395
Adult; Aged; Carcinoma, Squamous Cell; Cervical Intraepithelial Neoplasia; Confidence Intervals; DNA, Viral; Female; Follow-Up Studies; Human Papillomavirus DNA Tests; Humans; Middle Aged; Papillomaviridae; Papillomavirus Infections; RNA, Messenger; RNA, Viral; Sensitivity and Specificity; Triage; Uterine Cervical Neoplasms; Young Adult