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Direct Angiotensin II Type 2 Receptor Stimulation Ameliorates Insulin Resistance in Type 2 Diabetes Mice with PPARγ Activation

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Authors:
  • Ohshima, Kousei ;
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    unknown
  • Mogi, Masaki ;
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    unknown
  • Jing, Fei ;
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    unknown
  • Iwanami, Jun ;
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    unknown
  • Tsukuda, Kana ;
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    unknown
  • Min, Li-Juan ;
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    unknown
  • Ogimoto, Akiyoshi ;
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    unknown
  • Dahlöf, Björn ;
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    unknown
  • Steckelings, Ulrike Muscha ;
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    Kardiovaskulær og Renal Forskning, Department of Molecular Medicine, Faculty of Health Sciences, SDU
  • Unger, Tomas ;
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    unknown
  • Higaki, Jitsuo ;
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    unknown
  • Horiuchi, Masatsugu
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    unknown
DOI:
10.1371/journal.pone.0048387
Abstract:
The role of angiotensin II type 2 (AT(2)) receptor stimulation in the pathogenesis of insulin resistance is still unclear. Therefore we examined the possibility that direct AT(2) receptor stimulation by compound 21 (C21) might contribute to possible insulin-sensitizing/anti-diabetic effects in type 2 diabetes (T2DM) with PPARγ activation, mainly focusing on adipose tissue.
Type:
Journal article
Language:
English
Published in:
P L O S One, 2012, Vol 7, Issue 11
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2012
Scientific Level:
Scientific
ID:
232832234

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