Dalsgaard, Petur W.3; Petersen, Bent O.4; Duus, Jens Ø.5; Zidorn, Christian6; Frisvad, Jens Christian7; Christophersen, Carsten3; Larsen, Thomas Ostenfeld8
1 Department of Systems Biology, Technical University of Denmark2 Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark3 University of Copenhagen4 Carlsberg Laboratory5 unknown6 Leopold-Franzens-Universität7 Fungal Chemodiversity, Department of Biotechnology and Biomedicine, Technical University of Denmark8 Natural Product Discovery, Department of Biotechnology and Biomedicine, Technical University of Denmark
Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.