1 Ditzel group, Department of Molecular Medicine, Det Sundhedsvidenskabelige Fakultet, SDU2 Oncology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU3 Ditzel group, Department of Molecular Medicine, Det Sundhedsvidenskabelige Fakultet, SDU
In this study, we have investigated the expression of the tumor antigen sperm protein 17 (SP17) in a large panel of human cancers and compared it with the expression of two well-characterized families of tumor antigens, melanoma-associated antigen-A (MAGE-A) and G antigen (GAGE). We found that SP17 was expressed in many cancer types with an overall frequency of 12%. SP17 was most frequently expressed in a different set of cancer types than MAGE-A and GAGE antigens and rarely overlapped with these proteins. Importantly, SP17 expression was limited to a small number of scattered cancer cells in most positive tumors in contrast to MAGE-A and GAGE proteins, which were homogenously expressed in large foci. Our results suggest that SP17 may not be an optimal target for cancer vaccines.