The metabolic profile of long-lived Drosophila melanogaster

Pernille Merete Sarup; Simon Metz Pedersen; Niels Christian Nielsen; Anders Malmendal; Volker Loeschcke

doi:10.1371/journal.pone.0047461

The metabolic profile of long-lived Drosophila melanogaster

Authors:

Sarup, Pernille Merete ;
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0000-0002-5838-1251
Department of Bioscience - Genetics, Ecology and Evolution, Department of Bioscience, Science and Technology, Aarhus University
Pedersen, Simon Metz ;
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Department of Chemistry, Faculty of Science, Aarhus University, Aarhus University
Nielsen, Niels Christian ;
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Department of Chemistry, Science and Technology, Aarhus University
Malmendal, Anders ;
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Afd. for Celle og Metabolismeforskning
Loeschcke, Volker
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Department of Bioscience - Genetics, Ecology and Evolution, Department of Bioscience, Science and Technology, Aarhus University

DOI:

10.1371/journal.pone.0047461

Abstract:

We investigated the age-related changes in the metabolic profile of male Drosophila melanogaster and compared the metabolic profile of flies selected for increased longevity to that of control flies of equal age. We found clear differences in metabolite composition between selection regimes and among age groups. Contrary to results found in a previous study of the transcriptome of these lines the metabolic profile did not show a younger pattern in longevity-selected (LS) flies than in same aged control (C) flies. Rather, many of the metabolites affected by age had levels common to older control individuals in the young LS flies. Furthermore, ageing affected the metabolome in a different LS specific direction. The selection induced difference increased with age. Some metabolites involved in oxidative phosphorylation changed with age highlighting the importance of mitochondrial function in the ageing process. However, these metabolites were not affected by selection for increased longevity, indicating that improvements of mitochondrial function was not involved in the increased lifespan of LS lines. Of the eight metabolites identified as having a significant difference in relative abundance between selection regimes in our study choline, lysine and glucose also show difference among lifespan phenotypes in C. elegans indicating that the correlation between the concentration of these metabolites and longevity was evolutionary conserved. Links between longevity and choline concentration is also found in mice making this metabolite an obvious target for further study.

Type:

Journal article

Language:

English

Published in:

P L O S One, 2012, Vol 7, Issue 10

Main Research Area:

Science/technology

Publication Status:

Published

Review type:

Peer Review

Submission year:

2012

Scientific Level:

Scientific

ID:

232218134

The metabolic profile of long-lived Drosophila melanogaster

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