Orr, Nick2; Lemnrau, Alina2; Cooke, Rosie2; Fletcher, Olivia2; Tomczyk, Katarzyna2; Jones, Michael2; Johnson, Nichola2; Lord, Christopher J2; Mitsopoulos, Costas2; Zvelebil, Marketa2; McDade, Simon S2; Buck, Gemma2; Blancher, Christine2; Trainer, Alison H2; James, Paul A2; Bojesen, Stig E3; Bokmand, Susanne1; Nevanlinna, Heli2; Mattson, Johanna2; Friedman, Eitan2; Laitman, Yael2; Palli, Domenico2; Masala, Giovanna2; Zanna, Ines2; Ottini, Laura2; Giannini, Giuseppe2; Hollestelle, Antoinette2; Ouweland, Ans M W van den2; Novaković, Srdjan2; Krajc, Mateja2; Gago-Dominguez, Manuela2; Castelao, Jose Esteban2; Olsson, Håkan2; Hedenfalk, Ingrid2; Easton, Douglas F2; Pharoah, Paul D P2; Dunning, Alison M2; Bishop, D Timothy2; Neuhausen, Susan L2; Steele, Linda2; Houlston, Richard S2; Garcia-Closas, Montserrat2; Ashworth, Alan2; Swerdlow, Anthony J2
1 Breast Surgery, Herlev and Gentofte Hospital, The Capital Region of Denmark2 unknown3 Clinical Biochemistry, Herlev and Gentofte Hospital, The Capital Region of Denmark
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50).
Nature Genetics, 2012, Vol 44, Issue 11, p. 1182-4